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Prof Dr Warren Thomas

Senior Lecturer in Molecular Medicine (RCSI),
PU-RCSI Lead in Physiology,
PU-RCSI Junior Cycle Director

Qualifications:
PhD Microbiology, University of Reading, 1993
Postgrad Cert in Health Professions Education, RCSI, 2015
BSc hons Zoology and Microbiology, University of Aberystwyth, 1989

Alma Mater:
University of Aberystwyth, United Kingdom 1986-1989
University of Reading, United Kingdom 1989-1993

Subjects Taught:
Cardiovascular Physiology, Endocrinology, Renal Physiology, Neurophysiology.

Associations:
Biochemical Society (Member).
International Association for the Study of Lung Cancer, IASLC (Member).
Malaysian Society for Pharmacology and Physiology (Member).

About

Warren is a graduate in Biological Sciences from the University of Aberystwyth, Wales and was awarded a PhD by the University of Reading in 1993. His PhD project focused on characterizing outer membrane proteins from pathogenic spirochaete bacteria. Warren has held research positions at the Institute for Animal Health, Compton, UK where he worked on the molecular biology of poxviruses and birnaviruses, and at King’s College London where his research focused on the actions of bacterial toxins. In 2002 Warren joined the Department of Molecular Medicine, Royal College of Surgeons in Ireland (RCSI) as a Research Fellow, with projects focused on investigating the role of steroid hormones in normal physiology and disease processes. Warren moved to Malaysia in 2015 and joined the Perdana University -RCSI School of Medicine where he is Academic Lead in Physiology and Junior Cycle Teaching Director. Warren has 48 publications in peer reviewed journals including Annual Reviews in Physiology and PNAS.

Research Interests

Research Interests

  • Keywords:

Steroid Hormones, Malignancy, Mesothelioma, Sodium conservation, Kidney, Dengue, Aedes

  • Short description:

Since joining Perdana University Warren has maintained his research interests in the field of cancer biology and hypertension. He has also developed research interests in Population Health, and is a Management Committee Member for the AIM (Aedes Invasive Mosquitoes) Marie Sk?odowska-Curie COST-Action. This training network aims to integrate research activities across Europe with activities in areas of the World where mosquito-borne disease is endemic.

Publications

  1. Haziman A, Ravinderan S, Thangavelu T, Thomas W (2018). A novel role for oestrogen-induced signalling in the colorectal cancer gender bias. Irish J Medical Sci (Accepted). PMID: 30014247
  2. Harvey BJ and Thomas W (2018). Aldosterone-induced protein kinase signalling and the control of electrolyte balance. Steroids 133, 67-74. PMID: 29079406.
  3. Nolan AM, Bustos V, Nijhuis A, Parker A, Poulsom R, Harvey H, Thomas W, Harvey BJ, Silver A (2017). GPER mediates differential effects of estrogen on colon cancer cell proliferation and migration under normoxic and hypoxic conditions. Oncotarget, 48, 84258-84275. PMID: 29137421.
  4. Rapetti-Mauss R, Bustos V, Thomas W, McBryan J, Harvey H, Lajczak N, Madden SF, Borgese F, Pelissier B, Soriani O and Harvey BJ (2017). Bi-directional KCNQ1: beta-catenin interaction drives colorectal cancer cell differentiation. Proc. Natl. Acad. Sci. 114, 4159-4164. PMID: 28373572.
  5. Hian C-K, Lee C-L, Thomas W (2016). Renin-angiotensin-aldosterone system antagonism and polycystic kidney disease progression. Nephron 134, 59-63. PMID: 27476173.
  6. Jennings CJ, Zainal N, Dahlan IMM, Kay EW, Harvey BJ, Thomas W (2016). Tamoxifen suppresses the growth of malignant pleural mesothelioma cells. Anticancer Res. 36, 5905-5913. PMID: 27793915.
  7. Jennings CJ, Murer B, O’Grady A, Hearn LM, Harvey BJ, Kay EW, Thomas W (2015). Differential p16/INK4A cyclin-dependent kinase inhibitor expression correlates with chemotherapy efficacy in a cohort of 88 malignant pleural mesothelioma patients. Brit. J. Cancer. 113, 69-75. PMID: 26057448.
  8. Quinn S, Harvey BJ, Thomas W (2014). Rapid aldosterone actions on epithelial sodium channel trafficking and cell proliferation. Steroids 81, 43-48. PMID: 24269741.
  9. Jennings CJ, Walsh PM, Deady S, Harvey BJ and Thomas W (2014). Malignant pleural mesothelioma incidence and survival in the Republic of Ireland 1994 to 2009. Cancer Epidemiol. 38, 35-41. PMID: 24394956.
  10. Jennings CJ, Murer B, O’Grady A, Harvey BJ, Kay EW, Thomas W (2014). Steroid receptor coactivators and oestrogen receptor beta-1 as survival biomarkers in malignant pleural mesothelioma.  Anticancer Res. 34, 6206-6208.
  11. Yusef YR, Thomas W and Harvey BJ (2014). Oestrogen increases ENaC activity via PKC-delta signalling in renal cortical collecting ducts cells. Physiol. Rep. 2, e120120. PMID: 24872356.
  12. Yusef YR, Thomas W, Harvey BJ (2014). Physiological techniques in the study of rapid aldosterone effects. Methods Mol. Biol. 1204, 219-231. PMID 25182774.
  13. Dooley R, Angibaud E, Yusef YR, Thomas W, Harvey BJ (2013). Aldosterone-induced ENaC and basal Na+/K+-ATPase trafficking via protein kinase D1-phosphatidylinositol 4-kinaseIII? trans-Golgi signalling in M1 cortical collecting duct cells. Mol. Cell. Endocrinol. 372, 86-95. PMID: 23541637.  
  14. Byrne JC, Ní Gabhann J, Stacey K, Coffey B, McCarthy E, Thomas W, Jefferies CA (2013). Btk is required for apoptotic cell uptake via regulating the phosphorylation and localisation of calreticulin. J. Immunol. 190, 5207-5215. PMID: 23596312.

Book Chapter

Thomas W. Phospholipase A and Breast Cancer. In Phospholipases in Health and Disease, eds. Tappia PS and Dhalia NS, pp 101-114. Springer, New York (2014).

About

Warren is a graduate in Biological Sciences from the University of Aberystwyth, Wales and was awarded a PhD by the University of Reading in 1993. His PhD project focused on characterizing outer membrane proteins from pathogenic spirochaete bacteria. Warren has held research positions at the Institute for Animal Health, Compton, UK where he worked on the molecular biology of poxviruses and birnaviruses, and at King’s College London where his research focused on the actions of bacterial toxins. In 2002 Warren joined the Department of Molecular Medicine, Royal College of Surgeons in Ireland (RCSI) as a Research Fellow, with projects focused on investigating the role of steroid hormones in normal physiology and disease processes. Warren moved to Malaysia in 2015 and joined the Perdana University -RCSI School of Medicine where he is Academic Lead in Physiology and Junior Cycle Teaching Director. Warren has 48 publications in peer reviewed journals including Annual Reviews in Physiology and PNAS.

Research Interests

Research Interests

  • Keywords:

Steroid Hormones, Malignancy, Mesothelioma, Sodium conservation, Kidney, Dengue, Aedes

  • Short description:

Since joining Perdana University Warren has maintained his research interests in the field of cancer biology and hypertension. He has also developed research interests in Population Health, and is a Management Committee Member for the AIM (Aedes Invasive Mosquitoes) Marie Sk?odowska-Curie COST-Action. This training network aims to integrate research activities across Europe with activities in areas of the World where mosquito-borne disease is endemic.

Publications

  1. Haziman A, Ravinderan S, Thangavelu T, Thomas W (2018). A novel role for oestrogen-induced signalling in the colorectal cancer gender bias. Irish J Medical Sci (Accepted). PMID: 30014247
  2. Harvey BJ and Thomas W (2018). Aldosterone-induced protein kinase signalling and the control of electrolyte balance. Steroids 133, 67-74. PMID: 29079406.
  3. Nolan AM, Bustos V, Nijhuis A, Parker A, Poulsom R, Harvey H, Thomas W, Harvey BJ, Silver A (2017). GPER mediates differential effects of estrogen on colon cancer cell proliferation and migration under normoxic and hypoxic conditions. Oncotarget, 48, 84258-84275. PMID: 29137421.
  4. Rapetti-Mauss R, Bustos V, Thomas W, McBryan J, Harvey H, Lajczak N, Madden SF, Borgese F, Pelissier B, Soriani O and Harvey BJ (2017). Bi-directional KCNQ1: beta-catenin interaction drives colorectal cancer cell differentiation. Proc. Natl. Acad. Sci. 114, 4159-4164. PMID: 28373572.
  5. Hian C-K, Lee C-L, Thomas W (2016). Renin-angiotensin-aldosterone system antagonism and polycystic kidney disease progression. Nephron 134, 59-63. PMID: 27476173.
  6. Jennings CJ, Zainal N, Dahlan IMM, Kay EW, Harvey BJ, Thomas W (2016). Tamoxifen suppresses the growth of malignant pleural mesothelioma cells. Anticancer Res. 36, 5905-5913. PMID: 27793915.
  7. Jennings CJ, Murer B, O’Grady A, Hearn LM, Harvey BJ, Kay EW, Thomas W (2015). Differential p16/INK4A cyclin-dependent kinase inhibitor expression correlates with chemotherapy efficacy in a cohort of 88 malignant pleural mesothelioma patients. Brit. J. Cancer. 113, 69-75. PMID: 26057448.
  8. Quinn S, Harvey BJ, Thomas W (2014). Rapid aldosterone actions on epithelial sodium channel trafficking and cell proliferation. Steroids 81, 43-48. PMID: 24269741.
  9. Jennings CJ, Walsh PM, Deady S, Harvey BJ and Thomas W (2014). Malignant pleural mesothelioma incidence and survival in the Republic of Ireland 1994 to 2009. Cancer Epidemiol. 38, 35-41. PMID: 24394956.
  10. Jennings CJ, Murer B, O’Grady A, Harvey BJ, Kay EW, Thomas W (2014). Steroid receptor coactivators and oestrogen receptor beta-1 as survival biomarkers in malignant pleural mesothelioma.  Anticancer Res. 34, 6206-6208.
  11. Yusef YR, Thomas W and Harvey BJ (2014). Oestrogen increases ENaC activity via PKC-delta signalling in renal cortical collecting ducts cells. Physiol. Rep. 2, e120120. PMID: 24872356.
  12. Yusef YR, Thomas W, Harvey BJ (2014). Physiological techniques in the study of rapid aldosterone effects. Methods Mol. Biol. 1204, 219-231. PMID 25182774.
  13. Dooley R, Angibaud E, Yusef YR, Thomas W, Harvey BJ (2013). Aldosterone-induced ENaC and basal Na+/K+-ATPase trafficking via protein kinase D1-phosphatidylinositol 4-kinaseIII? trans-Golgi signalling in M1 cortical collecting duct cells. Mol. Cell. Endocrinol. 372, 86-95. PMID: 23541637.  
  14. Byrne JC, Ní Gabhann J, Stacey K, Coffey B, McCarthy E, Thomas W, Jefferies CA (2013). Btk is required for apoptotic cell uptake via regulating the phosphorylation and localisation of calreticulin. J. Immunol. 190, 5207-5215. PMID: 23596312.

Book Chapter

Thomas W. Phospholipase A and Breast Cancer. In Phospholipases in Health and Disease, eds. Tappia PS and Dhalia NS, pp 101-114. Springer, New York (2014).

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