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Charting the Viral-Human Shareome

May 22, 2020 @ 15:00 16:00 UTC+8

Sequences shared between viral-human proteomes are analogs or homologs that provide insight into the evolution of host-pathogen interactions. Shared sequences have been identified to be of value to viral survival, where they provide the means for molecular interaction with the host, progression of life cycle, facilitate immune evasion, alter the host metabolic processes, and even hijack host cellular machinery. These activities aid in viral pathogenicity of human diseases. A shared protein sequence is defined as one that is 100% identical (either partially or fully) between the viral and human proteomes. The role of shared sequences in viral survival, particularly in the mechanism of pathogenesis, is still obscure. A novel systematic bioinformatics approach was developed to map and characterized shared sequences between viral and human proteomes. Herein, the complete set of the shared sequences, is defined as the “shareome”, of viral-human proteomes is described and discussed.